Effect of adult T-cell leukemia cells on pokeweed mitogen-induced normal B-cell differentiation

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Abstract

Leukemic T cells from Japanese patients with adult T-cell leukemia were studied for their effects on pokeweed mitogen-induced peripheral blood lymphocyte differentiation into immunoglobulin-producing cells. Allogeneic peripheral blood lymphocytes, normal T cells, nonlymphoid leukemia cells, lymphoid leukemia cells other than adult T-cell leukemia cells, and long-term T-cell lines did not suppress normal B-cell differentiation in coculture experiments. Leukemic T cells from three of six patients with adult T-cell leukemia showed a marked suppressive effect. Supernatant fluids obtained from a short-term (48-hr) culture of leukemic T cells from one of these three patients also showed a marked suppressive effect on B-cell differentiation at a final dilution of 15 or less when added at the beginning of the culture (on Day 0) or on Day 1. Supernatant fluids, however, did not manifest suppressor activity when added on Day 3 or later, or when heated at 56°C for 30 min before addition.

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