Short communication
A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats

https://doi.org/10.1016/0041-008X(77)90083-7Get rights and content

Abstract

A simple, quantitative, sensitive, and objective method of early assessment of the degree of disability of rats with acrylamide-induced neuropathy by the measurement of landing foot-spread is described.

References (4)

There are more references available in the full text version of this article.

Cited by (133)

  • Palliative effect of Moringa olifera-mediated zinc oxide nanoparticles against acrylamide-induced neurotoxicity in rats

    2023, Food and Chemical Toxicology
    Citation Excerpt :

    A score of 4 pointed out to the severely affected rat, as evidenced by weak hind limbs and incompetence to rear and upkeep its weight. Edwards and Parker (1977) procedure for measuring landing foot spread distance (LFSD) was used. In short, the ink was applied to the rats' fourth hind digits and then dropped from a 30 cm horizontal height.

  • Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice

    2021, Toxicology
    Citation Excerpt :

    Human case reports of acrylamide intoxication have been reported after drinking well water containing 400 ppm acrylamide (Igisu et al., 1975; Morimoto, 1975). In the present study, the acrylamide exposure level was selected based on previous experimental studies (Edwards and Parker, 1977; Gilbert and Maurissen, 1982; Nagashima et al., 2019; Zong et al., 2019) and our preliminary studies, as well as human cases with neurological deficits associated with acrylamide intoxication. It should be noted that the weight of whole brain decreased following intake of acrylamide at 67 ppm in Nrf2-/- mice while no changes in hindlimb splay length, density of monoaminergic axons or mRNA level of the tested genes were observed.

View all citing articles on Scopus
View full text