Aeruginosins 98-A and B, trypsin inhibitors from the blue-green alga Microcystis aeruginosa (NIES-98)
Aeruginosins 98-A and B, trypsin inhibitors, were isolated from the cultured freshwater blue-green alga Microcystis aeruginosa. Their structures were elucidated to be 1 and 2, respectively on the basis of 2D NMR data and chemical degradation. These peptides inhibited trypsin potently with an IC50 of 0.6μg/ml.
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Cited by (129)
Detection of secondary cyanobacterial metabolites using LC-HRMS in Lake Karaoun
2023, Science of the Total EnvironmentCyanobacterial metabolites: Aeruginosin 98A, microginin-FR1, anabaenopeptin-A, cylindrospermopsin and their mixtures affect behavioral and physiological responses of Daphnia magna
2023, Environmental Toxicology and PharmacologyComplete sequence and structure of the genome of the harmful algal bloom-forming cyanobacterium Planktothrix agardhii NIES-204<sup>T</sup> and detailed analysis of secondary metabolite gene clusters
2021, Harmful AlgaeCitation Excerpt :Previously reported secondary metabolites were all correlated with these gene clusters (Table 2), and we analyzed these in detail with the information from the previously reported products; aeruginosin, however, has not been previously reported from P. agardhii NIES-204. Aeruginosins are nonribosomal peptides characterized by a unique 2-carboxy-6-hydroxyoctahydroindole (Choi) moiety that inhibits serine proteases (Murakami et al., 1994, 1995; Welker and von Döhren 2006). This type of peptide is produced by Planktothrix, Microcystis, and Nodularia (Welker and von Döhren 2006), and the corresponding biosynthetic gene clusters are known (Ishida et al., 2007, 2009; Fewer et al., 2013).
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Present address: Fusetani Biofouling Project, ERATO, Research Development Corporation of Japan, Isogo-ku, Yokohama 235, Japan.
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Present address: Central Research Laboratory, Nippon Suisan Co. Ltd., Kitano, Hachioji, Tokyo, 192, Japan.