2H-benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelminthic activity1.,2.
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Cited by (47)
Understanding field variation, quantum chemical modeling and molecular orbital analyses of trans-3-(trans-4-imidazolyl) acrylic acid
2017, Journal of Molecular StructureSynthesis and evaluation of anti-inflammatory, antioxidant and antimicrobial activities of densely functionalized novel benzo [d] imidazolyl tetrahydropyridine carboxylates
2017, Arabian Journal of ChemistryCitation Excerpt :Benomyl and Fuberidazole are used as antifungal agents. Benzimidazole derivatives are also reported to possess analgesic (Sondhi et al., 2002), anti-helminthic (Hazelton et al., 1995; Labaw and Webb, 1981), anti-inflammatory (Ito et al., 1982), antimicrobial, anti-arthritic, and anti-HIV activities (Rao et al., 2002). Several compounds consisting of reduced pyridine, like the 1,2,3,6-tetrahydropyridine 1 ring system shown in Fig. 1 are known to exhibit a variety of biological activities (Coutts and Casay, 1975; Ferles and Pliml, 1970).
Synthesis and in-silico molecular docking simulation of 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones as novel analgesic anti-inflammatory agent
2016, Arabian Journal of ChemistryCitation Excerpt :Benzimidazoles and their analogs are well known biologically active N-containing heterocycles (Kozo et al., 2001), widely used as drugs such as proton pump inhibitor (Omeprazole) (Langtry and Wilde, 1998), antihelmentic (Albendazole) (Hazelton et al., 1995), and anti-dopaminergic Domperidone (Kennis et al., 1986) anti-psychotic (Pimozide) (Meisel et al., 1987).
Synthesis, X-ray structure, theoretical investigation, corrosion inhibition and antimicrobial activity of benzimidazole thioether and theirs metal complexes
2016, PolyhedronCitation Excerpt :Benzimidazole derivatives are reported to be physiologically and pharmacologically active and have shown different biological activities such as antioxidant [1], antifungal [2], anthelminthic [3], antitumoral [4], anti-inflammatory [5] and antimicrobial [6,7].
Purine-benzimidazole hybrids: Synthesis, single crystal determination and in vitro evaluation of antitumor activities
2015, European Journal of Medicinal ChemistryCitation Excerpt :Some of their derivatives are marketed as anti-fungal agent such as Carbendazim [12], anti-helmintic agents such as Mebendazole and Thiabendazole [13] and anti-psychotic drug such as Pimozide [14]. In view of the previous rationale and in continuation of an ongoing program aiming at finding new structure leads with potential chemotherapeutic activities using molecular hybridization [15], new series of molecular hybrids using purine and benzimidazole have been synthesized and screened for in vitro antitumor activity as well as Aurora A kinase inhibitors. These series comprises the derived 2,6-disubstituted purine pharmacophore that are structurally related to Olomoucine and Roscovitine.
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Part 9: Hazelton, J.C.; Iddon, B. ; Redhouse, A.D.; Suschitzky, H. Tetrahedron 1995, 51, 5597.
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For a review of earlier work and a preliminary announcement of this work see Iddon, B. Bull. Soc. Chim. Belg. 1990, 99, 673.