The rate of approach to equilibrium in uncatalyzed CO2 hydration reactions: The theoretical effect of buffering capacity☆
References (15)
- et al.
The effect of variation in ionic strength on the apparent first and second dissociation constants of carbonic acid
J. Biol. Chem.
(1925) On the measurement of buffer values and on the relationship of buffer value to the dissociation constant of the buffer and the reaction of the buffer solution
J. Biol. Chem.
(1922)- et al.
Carbonic anhydrase inhibitors
Pharmacol. Rev.
(1956) - et al.
Biophysical Chemistry
(1958) - et al.
Rate limiting processes in the Bohr shift in human red cells
J. Physiol. (London)
(1968) Die Bindungsweise des Kohlendioxyds in Blute
Biochem. Z.
(1928)On the carbon dioxide compounds in hemoglobin solutions
J. Biol. Chem.
(1931)
Cited by (18)
A method to monitor urinary carbon dioxide in patients with septic shock
2016, Sensors and Actuators, B: ChemicalCitation Excerpt :According to our hypothesis, the CO2 partial pressure (CO2(g)) in the bladder is in equilibrium with the dissolved CO2 (CO2(aq)) in the urine regardless of urine pH. The hydration of CO2 and dehydration of H2CO3 are relatively slow reactions (half time 0.3–30 s); however in living systems the enzyme carbonic anhydrase significantly speed up the rate at which H2CO3 and CO2 equilibrate. We also expect that in the absence of carbonic anhydrase catalysis the hydration of CO2 and dehydration of H2CO3 likely proceed quickly enough follow slow changes in the local CO2 levels in surrounding tissue in the abdominal area due to gradual changes in the tissue perfusion [25]. To model the conditions in the bladder, citrate/phosphate (C&P) buffer solutions with physiologically relevant pH’s 4.0, 4.5, 5.5, and 6.5 were saturated with CO2/N2 gas mixtures with partial pressures 25, 38, and 76 mmHg CO2.
3 Carbonic Anhydrase and Respiratory Gas Exchange
1998, Fish Physiology9 Causes and Consequences of Acid-Base Disequilibria
1998, Fish PhysiologyThe disequilibrium pH: A tool for the localization of carbonic anhydrase
1998, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyAmount and rates of CO<inf>2</inf> storage in lung tissue
1976, Respiration Physiology
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Work supported by grant HE 02888-12 of the National Heart Institute, National Institutes of Health.
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Supported by Medical Scientist Program of the Life Insurance Medical Research Fund.