ArticleEffects of haloperidol on the acquisition of a spatial learning task
References (30)
- et al.
The effects of ibotenic acid lesions of the nucleus accumbens on spatial learning and extinction in the rat
Behav. Brain Res.
(1989) The role of dopamine in locomotor activity and learning
Brain Res. Rev.
(1983)- et al.
Evidence that dopamine in the nucleus accumbens is involved in the ability of rats to switch to cue-directed behaviours
Behav. Brain Res.
(1991) Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: Facilitation of processes involved in selecting the best strategy in a stressful situation
Behav. Brain Res.
(1980)- et al.
Role of neostriatum and nucleus accumbens in stepping induced by appomorphine and dexamphetamine
Brain Res. Bull.
(1991) - et al.
Memory impairments following basal forebrain lesions
Brain Res.
(1985) - et al.
Spatial learning in rats: Correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage
Exp. Neurol.
(1989) The role of noradrenaline in tuning and dopamine in switching between signals in the CNS
Neurosci. Biobehav. Rev.
(1985)- et al.
Approach, avoidance and contact behaviour of individually recognized animals automatically quantified with an imaging technique
Physiol. Behav.
(1992) - et al.
Spatial mapping: Definitive disruption by hippocampal or medial frontal cortical damage in the rat
Neurosci. Lett.
(1982)
Bovine serum albumin—haloperidol as a tool for the study of dopaminergic transmission: Behavioural and neurochemical effects following a single injection in the nucleus accumbens
Life Sci.
Further evidence for the role of the caudate nucleus in programming motor and non-motor behaviour in Java monkeys
Exp. Neurol.
Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behaviour in rats
Brain Res.
Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues
Behav. Brain Res.
Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in rats
Behav. Brain Res.
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2021, Neuroscience LettersCitation Excerpt :Table 1). Haloperidol impaired spatial learning in intact animals [35–37] and was largely ineffective in countering cognitive deficit caused by MK-801 administration in MWM and CM [16,37–39]. Although haloperidol reduced the number of entrances in CM, it resulted from decreased rat locomotion and the number of entrances corresponded to the number of arena’s laps (20 laps per 20-minute session) [36].
Presynaptic D<inf>2</inf> dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus
2015, Biological PsychiatryCitation Excerpt :Given the drastic changes in synaptic plasticity and the dopaminergic circuit remodeling observed in D2KO and sulpiride-treated mice, we anticipated downstream functional impairments in hippocampus-dependent learning and memory processes. Systemic administration of D2-like antagonists in rats had been shown to trigger learning and memory deficits (28,30,32,60–62). The profound deficits in both LTP and LTD observed in D2KO mice were associated with dramatic impairments in three hippocampus-dependent learning and memory paradigms: the spatial MWM, the Barnes maze, and the novel object recognition task.
Chronic haloperidol-induced spatial memory deficits accompany the upregulation of D<inf>1</inf> and D<inf>2</inf> receptors in the caudate putamen of C57BL/6 mouse
2012, Life SciencesCitation Excerpt :Therefore, the results of the second study did not necessarily repel the conclusion inferred from the first study. Indeed, both the over-stimulation (Oades et al., 1985; Sarter et al., 1988) and blockade of D2 receptors (Ploeger et al., 1992; the present study) impair the spatial working memory of animals as discussed above. Further supporting evidence to our conclusion came from a recent study, in which over-expression of D2 receptors selectively in the striatum of the D2 transgenic mice led to impairment in tasks that require working memory and behavioral flexibility (Kellendonk et al., 2006).