ArticleEffects of pimozide on appetitive behavior and locomotor activity: Dissimilarity of effects when compared to extinction
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Cited by (26)
Microstructure analysis of the effects of the cannabinoid agents HU-210 and rimonabant in rats licking for sucrose
2020, European Journal of PharmacologyCitation Excerpt :However, the concomitant intra-burst lick rate reduction suggests caution in interpreting this as an anhedonic effect. Indeed, a number of studies suggest that the extinction-like pattern observed after neuroleptic administration – and HU-210 resembles neuroleptics in many respects (Ottani et al., 2002) – might be explained more parsimoniously in terms of motor effects than in terms of anhedonia (Rick et al., 2006; Salamone, 1986; Sanger, 1986; Spivak; Amit, 1986; Tombaugh et al., 1980, 1982; see also D'Aquila et al., 2019). Experiment 2 was performed to explore the possibility that the effect of HU-210 on lick number, which is an index of ingestion level (D'Aquila, 2010; Spector et al., 1998), could be dissociated from the effect on the intra-burst lick rate, which is an index of motor competence (Fowler and Mortell, 1992; Gramling and Fowler, 1986; Gramling et al., 1984).
The effects of haloperidol on cocaine-induced conditioned taste aversions
2012, Physiology and BehaviorCitation Excerpt :Although suggestive of a role for DA in cocaine's aversive effects, under this procedure pimozide unconditionally suppressed saccharin consumption prior to the pairing of saccharin with cocaine, introducing a potential confound of amount consumed as a factor in the differential acquisition of aversions [compared to saline-pretreated subjects who drank at high levels at the outset of conditioning; see 24,25, but see also 26, see 27 for a discussion]. Further, pimozide may have affected sensory processes that could have impacted the acquisition of the aversion independent of any antagonism of cocaine's specific aversive effects [28–30]. The present studies attempted to address the role of DA in the aversive effects of cocaine directly by examining the effects of the DA antagonist haloperidol on cocaine-induced taste aversions using procedures that circumvented the abovementioned possible effect of near maximal suppression [17] and the intrusion of any possible confounds of the DA antagonist [16].
Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: Effects of pimozide (Orap) in rats
2005, Pharmacology Biochemistry and Behavior