Elsevier

Neuropharmacology

Volume 26, Issue 1, January 1987, Pages 55-60
Neuropharmacology

Noradrenergic involvement in catalepsy induced by Δ9-tetrahydrocannabinol

https://doi.org/10.1016/0028-3908(87)90044-XGet rights and content

Abstract

In order to elucidate the role of the catecholaminergic system in the cataleptogenic effect of Δ9-tetrahydrocannabinol (THC), the effect of pretreatment with 6-hydroxydopamine (6-OHDA) or with desipramine and 6-OHDA and lesions of the locus coeruleus were investigated in rats. The cataleptogenic effect of THC was significantly reduced in rats treated with 6-OHDA and in rats with lesions of the locus coeruleus but not in rats treated with desipramine and 6-OHDA, as compared with control rats. On the contrary, the cataleptogenic effect of haloperidol was significantly reduced in rats treated with desipramine and 6-OHDA but not in rats treated with 6-OHDA or in rats with lesions of the locus coeruleus. These results indicate that noradrenergic neurons have an important role in the manifestation of catalepsy induced by THC, whereas dopaminergic neurons are important in catalepsy induced by haloperidol.

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Present addresses: 2nd Department of Pharmacology, School of Medicine, Nagasaki University, Nagasaki 852, Japan.

Present addresses: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-01, Japan.

Department of Pharmacology, Okayama University Medical School, Okayama 700, Japan.

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