The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia
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2024, Journal of Environmental Chemical EngineeringComparison of anaesthetic- and seizure-induced states of unconsciousness: a narrative review
2021, British Journal of AnaesthesiaCitation Excerpt :It has previously been described that cats administered ketamine anaesthesia produced bursts of hypersynchronous slow waves on EEG.176 These slow waves were rhythmic, synchronous, and frequently accompanied by spikes, forming a spike-and-wave complex.176–179 Moreover, in many neurones, neuronal activity was modified during the slow wave bursts that mimic patterns observed during experimental seizures.176,177
Ketamine-induced muscle rigidity during procedural sedation mitigated by intravenous midazolam
2017, American Journal of Emergency MedicineEEG in non-clinical drug safety assessments: Current and emerging considerations
2016, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :The distinction between muscular changes and actual EEG spike activity dramatically affect the clinical understanding of these effects. Similarly, drug induced catalepsy may be incorrectly defined as convulsion (Bricker, Sampson, & Ablordeppey, 2014; Heitz & Bence, 2013; Sanberg, Bunsey, Giordano, & Norman, 1988; Winters, Ferrar-Allado, Guzman-Flores, & Alcaraz, 1972), again with EEG serving as a key biomarker for proper identification of the drug induced effect. Once a true seizure profile has been identified the finding should be put into perspective to improve clinical safety.
Pathological mechanism of musculoskeletal manifestations associated with CRPS type II: An animal study
2014, PainCitation Excerpt :We conducted an additional experiment with 6 rats in each group to evaluate the contribution of supraspinal mechanisms to the development of contracture. In this experiment, measurement was carried out in exactly the same way, but rats were anesthetized with ketamine, an N-methyl-D-aspartate receptor antagonist that induces transient catalepsy by affecting dopaminergic systems, rather than with pentobarbital [15,19,48]. Rats were anesthetized with intraperitoneal injection of ketamine hydrochloride (75 mg/kg body weight) (Ketalar 10 mg/mL; Daiichi-Sankyo, Tokyo, Japan).
Ketamine-induced catalepsy during adult sedation in the Emergency Department
2013, Journal of Emergency MedicineCitation Excerpt :Catalepsy has been described with ketamine in the veterinary literature with administration to feline and rat models. Animal studies found the duration of catalepsy to be a dose-dependent response, and electroencephalograms during this catatonic state reveal both a central nervous system excitation and depression (6). Additional animal studies found that pretreatment with morphine lowered the catalepsy threshold and augmented the response.
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New Address: Departments of Pharmacology and Family Practice, University of California School of Medicine, Davis, California, 95616.