Development of the vascular system in the hamster malignant neurilemmoma,☆☆

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Abstract

The development of the vasculature in the hamster malignant neurilemmoma was studied during growth in the transparent cheek pouch chamber. Prominent features in this process are: (1) Progressive dilatation, tortuosity and some bulbous formations in host venules in the immediate vicinity of the tumor implant. Occasional focal dilatation of some host arterioles. (2) Small focal erythrocytic extravasations. (3) Sprouting of host venous vessels in the perimeter of the implant and subsequent anastomosing of these sprouts and/or their branches to form loops directed toward the center of the implant. Continued sprouting, in effect, produces remodeling of the host venules. (4) Establishment of the tumor capillary net in 4–7 days. The bed assumes a dense net-like arrangement of short, profusely anastomosing, thin-walled endothelial tubes which conduct blood at a brisk rate. (5) Progressive increase in capillary caliber during tumor growth. (6) Prominent focal or general reduction in blood flow after about 10 days of growth. This appears related to the development of tissue growth pressure within the rigid cheek pouch chamber.

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Cited by (88)

  • The role of mechanical host-tumour interactions in the collapse of tumour blood vessels and tumour growth dynamics

    2006, Journal of Theoretical Biology
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    It is interesting to consider that the oscillatory phase of growth is characterized by a process of complete collapse and re-opening of the penetrating blood vessels. This complete opening and closing of the tumour vasculature was observed by Eddy and Casarett (1972) who examined the vascular system in the hamster malignant neurilemmoma by allowing the tumours to grow between the two perspex plates of the transparent cheek pouch chamber. A general reduction in the blood flow occurred after about ten days of growth, which the investigators associated with the development of a tissue growth pressure within the rigid cheek pouch chamber.

  • A history of the study of solid tumour growth: The contribution of mathematical modelling

    2004, Bulletin of Mathematical Biology
    Citation Excerpt :

    A number of key experimental studies of tumour vascular collapse have also appeared in the literature over the past four or five decades—another aspect of tumour biology which is known to be detrimental to anti-cancer therapies (Jain, 1994). In the study by Eddy and Casarett (1972), for example, the development of a ‘tissue growth pressure’ around a hamster malignant neurilemmoma in a restrictive transparent cheek pouch chamber was sufficient to compress the weak-walled tumor capillary vessels. Further, in the experiments reported by Goldacre and Sylven (1962), a harmless green dye was injected into the tail veins of mice with transplanted tumours, giving rise to a deep green coloration of the whole animal with the exception of the brain (due to the blood–brain barrier) and the central regions of many of the solid tumours.

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This paper is based on work supported in part by the U.S. Public Health Service Grant CA-11051, and in part under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project and has been assigned Report No. UR-3490-208.

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Presented in part at the 20th Annual Meeting of the Microcirculatory Society, 8–9 April 1972, Atlantic City, N.J.

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