Pregnancy in a patient with homozygous familial hypercholesterolemia treated with long-term low-density lipoprotein apheresis
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Cited by (49)
A complicated pregnancy in homozygous familial hypercholesterolaemia treated with lipoprotein apheresis: A case report
2019, Atherosclerosis SupplementsCitation Excerpt :Hemodynamic stress developing during pregnancy can exacerbate pre-existing cardiovascular lesions and precipitate into acute maternal events [8]. Furthermore, atherosclerosis may affect utero-placental circulation and lead to placental insufficiency, intrauterine growth restriction and preterm birth [14,15]. Oxidative stress and reduced antioxidant defence enhance free radicals possible causing vascular endothelial damage leading to pregnancy complications such as pre-eclampsia [8].
Lipoprotein apheresis is essential for managing pregnancies in patients with homozygous familial hypercholesterolemia: Seven case series and discussion
2016, AtherosclerosisCitation Excerpt :Managing these patents during child-bearing age presents many challenges for clinicians because LDL-C increases during gestation, statins and ezetimibe are contraindicated during pregnancy and lactation, and some patients may have aortic-valve disease and CAD. Therefore, LA is regarded as the most effective therapy to control LDL-C levels during pregnancy in patients with HoFH [4] [5] [6] [7]. However, only a few cases of pregnancy in HoFH patients have been reported and there is no guidance for overall management.
My Approach to the Patient With Familial Hypercholesterolemia
2016, Mayo Clinic ProceedingsSevere dyslipidemia in pregnancy: The role of therapeutic apheresis
2015, Transfusion and Apheresis ScienceCitation Excerpt :There are several evidence (case reports or case series) in which the authors describe the use of LDL apheresis successfully being performed in pregnant women largely with homozygous FH. This may be considered a therapeutic strategy in such individuals, especially those with elevated Lp(a) that has been shown to be effectively cleared by apheresis, when diet and drugs have failed [6,7,16,20,32–34]. In 2003 Klingel et al. [5] summarized experiences with 19 pregnancies of 16 patients with familial hyperlipoproteinemia, who became pregnant during chronic lipoprotein apheresis, or who were treated with lipoprotein apheresis because of acute disorders of lipid metabolism during pregnancy.
Pregnancy in homozygous familial hypercholesterolemia - Importance of LDL-apheresis
2015, Atherosclerosis SupplementsCitation Excerpt :The combination of HFH and pregnancy can be a fatal condition. In 1984, Kroon et al. reported that pregnancy in women with HFH is extremely rare and has a high mother and child mortality rate [10]. The prognosis of these patients has recently improved, however it still represents a serious medical problem with an estimated 30% possibility of acute coronary morbidity in mother or child [12].
Management of familial hypercholesterolemia during pregnancy: Case series and discussion
2012, Journal of Clinical Lipidology