Effects of AOMA on cholesterol metabolism in man☆
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Cited by (24)
Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease
2014, Biochemical and Biophysical Research CommunicationsCitation Excerpt :This formulation had an inherent cholesterol content of 0.02% (w/w) [28]. For one study, the meal form of this diet was made to contain either additional cholesterol (0.5% w/w) or surfomer (AOMA, a co-polymer of maleic acid and an 18-carbon α-olefin) [29] at a level of 2% (w/w) [15]. Ezetimibe was added to the diet at a level of 0.0125% (w/w) which provided an approximate dose of 20 mg/day/kg bw [27].
Plasma noncholesterol sterols as indicators of cholesterol absorption 1
2013, Journal of Lipid ResearchDelineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption
2005, Journal of Lipid ResearchCitation Excerpt :Similar results have been reported for apolipoprotein E*3-Leiden transgenic mice fed a high-cholesterol diet containing plant stanol esters (44). Previous studies in humans given various agents that inhibit cholesterol absorption found no adverse effects on biliary cholesterol saturation (45–48). The final point relates to the pathophysiologic relevance of these data to the cause and treatment of atherosclerosis in humans.
Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte
2002, Journal of Lipid ResearchCitation Excerpt :The data for SCH 58053 presented here yield several important new insights into the likely mechanism of action of this class of absorption inhibitor. Unlike agents such as sitostanol, sucrose polyester, or surfomer, which act at the level of the intraluminal phase of cholesterol absorption (6, 44, 49), this is apparently not the case with SCH 58053. This follows from several observations, the main one being that the level of absorption fell by almost half in the face of a normal bile acid pool size and composition.
Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster
1995, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
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Supported in part by the Medical Research Service of the Veterans Administration, NIH Research grant HL-14197, awarded by the National Heart, Lung and Blood Institute, and The Monsanto Company.
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