Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol☆
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Cited by (112)
Challenges in timing and mode of delivery in morbidly obese women
2024, Best Practice and Research: Clinical Obstetrics and GynaecologyThe 24-hour average concentration of cortisol is elevated in obese African-American youth with type 2 diabetes
2021, Journal of Diabetes and its ComplicationsCitation Excerpt :Many of the normal stature but obese youth had IC-GH and IC-F levels which were in the range typical of short, poorly-growing children with hypopituitarism.6 IC-cortisol has also been found to be lower in some populations of obese adults without diabetes7–9 compared to lean individuals. Potentially, lower circulating levels of cortisol and growth hormone would be less antagonistic to insulin, thus reducing insulin resistance which might help to prevent dysglycemia.10,11
Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats
2020, Molecular MetabolismCitation Excerpt :Elevated circulating glucocorticoid levels result in Cushing's Syndrome, which has many of the metabolic features seen in obesity, including elevated body weight, increased adiposity and insulin resistance. However, circulating glucocorticoid levels are not elevated in non-Cushing's Syndrome obesity [3]. Glucocorticoids exist in active (corticosterone in rodents and cortisol in humans) and inactive forms (11-dehydrocorticosterone in rodents and cortisone in humans) and only active glucocorticoids can activate the glucocorticoid receptor.
The cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome
2017, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Further studies found a correlation between elevated glucocorticoid action, insulin resistance, hyperglycemia and hypertension [20,43,44]. But a study in obese women showed decreased plasma cortisol level suggesting increased metabolic clearance [45]. In obese humans, an increased 11β-HSD1 activity was observed [22,23].
The effect of fetal growth and nutrient stresses on steroid pathways
2016, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :At present the effects of over-nutrition during human pregnancy on the offspring HPA axis are not known. Obesity in non-pregnancy is associated with dysregulation of the HPA axis, notably with activation of the axis but with associated increased hepatic metabolism and renal excretion of cortisol, ultimately leading to normal or lower levels of circulating cortisol [99–101]. If this dysregulation of the HPA axis is maintained during pregnancy, it is possible that the offspring of obese women may be exposed to altered glucocorticoid levels, and that this could impact upon fetal size and risk of disease later in life.
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Supported in part by Grants RR-53, CA-07304, and CA-22795 from the National Institutes of Health.