Pharmacokinetic model of intravitreal drug injection
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Cited by (33)
Ocular pharmacokinetics
2022, Handbook of Basic and Clinical Ocular Pharmacology and TherapeuticsVirtual pharmacokinetic model of human eye
2014, Mathematical BiosciencesCitation Excerpt :In the models of Tojo et al. [8,9] the eye was modeled as a cylinder and the partial differential equations were solved with the method of lines. Wyatt modeled drug transport from the anterior chamber [10], using a self-made finite element algorithm. Transscleral drug delivery has been considered by Balachandran and Barocas [11] and Narasimhan and Vishnampet [12].
Computational modeling of drug distribution in the posterior segment of the eye: Effects of device variables and positions
2014, Mathematical BiosciencesCitation Excerpt :Also, several factors in intravitreal injection or ocular implantation affect local drug concentrations, that these effects should be determined properly to achieve precise drug level at target tissues. So far, several computational models have been developed to simulate drug distribution in the vitreous humor [10–21]. Some studies developed a transport model following intravitreal injection from a point source [10–15,17,18,20] while the others simulated drug administration by an intraocular or periocular implant [15,16,19].
Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: Effect of dose and physicochemical properties
2012, Journal of Pharmaceutical SciencesCitation Excerpt :Vitreal pharmacokinetic parameters of hesperidin, hesperetin, and hesperidin G are presented in Tables 1, 2, and 3, respectively. Following intravitreal administration of a compound, it will be distributed within the vitreous humor and into the surrounding ocular tissues (retina, choroid, lens, and aqueous humor), from where elimination may take place.14 Distribution of an intravitreally administered drug is governed by (1) the gel structure of the vitreous humor and (2) the time taken by the compound to set up equilibrium with the peripheral ocular tissues.
Potential of liposomes for the intravitreal injection of therapeutic molecules
2011, Annales Pharmaceutiques FrancaisesComputational modeling of intravitreal drug delivery in the vitreous chamber with different vitreous substitutes
2008, International Journal of Heat and Mass Transfer