Elsevier

Life Sciences

Volume 58, Issue 16, 15 March 1996, Pages 1315-1321
Life Sciences

Extracts of ginkgo biloba leaves inhibit monoamine oxidase

https://doi.org/10.1016/0024-3205(96)00097-5Get rights and content

Abstract

Extracts of Ginkgo biloba leaves produce reversible inhibition of rat brain monoamine oxidase (MAO). Both MAO-A and -B types were inhibited to a similar extent. The MAO inhibitory compound(s) were present in dried or fresh Ginkgo biloba leaves as well as in commercially available capsules of Ginkgo biloba and appear to be heat stable with relatively low molecular weight. MAO inhibition by Ginkgo biloba may be a mechanism underlying reported anti-stress and anxiolytic activities of this natural product.

References (17)

  • J.R. Rapin et al.

    Gen. Pharmac

    (1994)
  • A.E. Hagerman et al.

    J. Biol. Chem.

    (1981)
  • D.L. Murphy et al.

    Psychiatr. Clin. North Am

    (1984)
  • M. Auguet et al.

    Gen. Pharmacol.

    (1982)
  • F.V. Defeudis

    Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications

  • K. Weinges et al.

    Justus Liebig's Ann. Chem.

    (1969)
  • K. Drieu

    Presse Méd.

    (1986)
  • J. Filep et al.

    Ginkgolides - Chemistry, Biology, Pharmacology and Clinical Perspectives

There are more references available in the full text version of this article.

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