Pharmacology letterHispidulin protection against hepatotoxicity induced by bromobenzene in mice
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Cited by (37)
Multi-target-based polypharmacology prediction (mTPP): An approach using virtual screening and machine learning for multi-target drug discovery
2022, Chemico-Biological InteractionsCitation Excerpt :The mTTP model based on the GBR algorithm showed better performances over the MLP, SVR and DTR algorithm and predicted 20 candidates which had a potential hepatoprotective effect. Next, Chelerythrine and Biochanin A, 2 of the 20 candidates, could improve the viability of APAP-induced injury cells, and works of literature have shown that among the 20 candidates, formononetin [47], glycitein [48], atranorin [49] and hispidulin [50] have hepatoprotective effects, indicating the accuracy of the mTTP model. Therefore, the mTPP model has good predictivity and applicability for multi-target drug discovery.
The hepatoprotective effects of Salvia plebeia R. Br. extract in zebrafish (Danio rerio)
2019, Fish and Shellfish ImmunologyCitation Excerpt :For example, the homoplantaginin isolated from the S. plebeia has a protective effect on oxidative stress-induced hepatocyte injury in vivo and in vitro [30,31]. The flavonoid hispidulin has been observed to prevent bromobenzene-induced liver injury in mice [32]. In addition, the SPEE significantly decreased induced nitric oxide synthase (iNOS) and ROS in the LPS-stimulated RAW264.7 cells [33,34].
Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report
2017, Journal of Traditional and Complementary MedicineCitation Excerpt :Hispidulin at the highest dose was able to counteract reduced glutathione depletion induced by bromobenzene in starved mice. This hepatoprotective effect of hispidulin could be due to its antioxidant potentials.35 Hispidulin, nepetin and jaceosidin were isolated from Eupatorium arnottianum Griseb and their anti-inflammatory activities were investigated in the TPA mouse ear edema and were found to be active.
Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice
2015, Journal of EthnopharmacologyCitation Excerpt :Here, we also identified hispidulin and acacetin from CI. Hispidulin has been shown to have several pharmacological actions, including inhibiting ileal contraction by interfering with Ca2+ signaling in smooth muscle cells (Abdalla et al., 1988), inhibiting platelet aggregation by cAMP elevation (Bourdillat et al., 1988) and protecting hepatocytes against bromobenzene-induced cytotoxicity (Ferrandiz et al., 1994). It also had anti-cancer activity in human HepG2 cells (Gao et al., 2014), glioblastoma cells (Lin et al., 2010) and pancreatic cancer cells (He et al., 2011), and anti-osteoporotic activity (Nepal et al., 2013; Zhou et al., 2014).
Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis
2008, Journal of EthnopharmacologyEffects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats
2006, Experimental Gerontology