Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages
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Immunotoxicology of Drugs of Abuse
2018, Comprehensive Toxicology: Third EditionEffect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques
2013, Journal of NeuroimmunologyCitation Excerpt :It is well established that the activation of opioid receptors by the administration of morphine, or other selective or non-selective opioid agonists, alters both innate immune competence and adaptive immune competence. Acute administration studies conducted in vitro with cell culture, or in vivo analysis with rodents, have demonstrated modulation of antibody responses (Taub et al., 1991; Guan et al., 1994; Eisenstein et al., 1995), phagocytic cell function (Rojavin et al., 1993; Szabo et al., 1993), natural killer (NK) cell activity (Weber and Pert, 1989), and the development and function of T cells in the thymus (Linner et al., 1996; McCarthy and Rogers, 2001; McCarthy et al., 2001) with opioid administration. Previous studies have shown that the production of IL-2 and IFNγ was inhibited following subcutaneous administration of morphine to rats (Lysle et al., 1993).
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