Elsevier

Life Sciences

Volume 48, Issue 18, 1991, Pages 1685-1704
Life Sciences

Minireview
Biologically active peptides in the gastrointestinal lumen

https://doi.org/10.1016/0024-3205(91)90205-PGet rights and content

Abstract

The release of a variety of biologically active peptides into the gastrointestinal lumen via gastric, duodenal and intestinal secretions, as well as in the saliva, pancreatic juice and bile, has been explored. The key features of luminal secretion of peptides such as secretion at high concentrations, neurohormonal regulation, luminal orientation of stimulated secretion, stability of peptides in the gastrointestinal lumen, altered secretion under pathophysiological conditions, and biological activity of luminally administered peptides are discussed. This review develops a detailed picture of the current understanding of luminal secretion of peptides and their possible biological functions under normal and pathophysiological conditions.

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