Vibration perception and thermoperception as quantitative measurements in the monitoring of cisplatin induced neurotoxicity

doi:10.1016/0022-510X(89)90187-1

Journal of the Neurological Sciences

Volume 93, Issues 2–3, November 1989, Pages 167-174

https://doi.org/10.1016/0022-510X(89)90187-1 Get rights and content

Abstract

In 20 ovarian cancer patients treated by cisplatin-based chemotherapy quantitative investigations of the vibration and the thermoperception were performed. Following the administration of cisplatin of 300 mg/m² and more the vibration perception threshold (VPT) was shown to be significantly elevated in all patients, despite the absence of clinical symptoms and signs in a number of patients. The VPT returned within 8 months to its original level in the 2 patients who were followed after cessation of therapy (cumulative dose of cisplatin 450–525 mg/m²). The changes seen in hands and in feet were comparable. There was no significant difference between the left and the right hand side. Thermoperception thresholds did not change during the treatment period. This study shows that quantitative measurement of vibration perception thresholds in patients treated with cisplatin is a relatively simple, accurate and reliable technique. Measurement is only required at the hand. It is concluded that this technique is a valuable tool in the assessment of cisplatin neurotoxicity and may be used in the monitoring of drugs that claim to be of benefit in the prevention and treatment of this affliction.

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Citation Excerpt :
Sensory perception thresholds can be used to monitor the course of cisplatin neuropathy. The vibration perception threshold was significantly increased in all patients after treatment with 300 mg/m² cisplatin (Elderson et al., 1989). The exact mechanism of cisplatin neurotoxicity is unclear.
Peripheral neuropathy is a common side‐effect of a number of cytostatic drugs of which vinca‐alkaloids, platinum compounds, and taxanes are the most important. The neuropathies caused by several groups of cytostatic compounds will be reviewed in this chapter. The clinical characteristics, neurophysiological findings, pathogenesis and natural course will be discussed together with several attempts that have been undertaken to ameliorate the neurotoxic effects.
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Review articleVibration perception and thermoperception as quantitative measurements in the monitoring of cisplatin induced neurotoxicity

Abstract

Detection thresholds of cutaneous sensation in humans

Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man

Ann. Neurol.

Method for quantitative estimation of thermal thresholds in patients

J. Neurol. Neurosurg. Psych.

Neuropathie au cisplatine etude clinique, electrophysiologique et morphologique

Rev. Neurol.

Standardised method of determining vibratory perception thresholds for diagnosis and screening in neurological investigation

J. Neurol. Neurosurg. Psych.

Quantitative vibration perception thresholds in healthy subjects of working age

Eur. J. Appl. Phys. Occ. Phys.

Review article
Vibration perception and thermoperception as quantitative measurements in the monitoring of cisplatin induced neurotoxicity