Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat☆,☆☆
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2017, American Journal of PathologyCitation Excerpt :The treatment regimens included vancomycin (Vcm; 500 mg/L, Gram-positive coverage), polymyxin B (PolyB; 100 mg/L, Gram-negative coverage), and Abx (broad-spectrum coverage) that included ampicillin (1 g/L), neomycin (1 g/L), metronidazole (1 g/L), and vancomycin (500 mg/L) in drinking water for 12 weeks. All three treatments have been shown to disrupt the gastrointestinal microbiota.24,25 Serum alanine aminotransferase (ALT; Pointe Scientific, Canton, MI) and lipopolysaccharide (Thermo Fisher Scientific, Rockford, IL) levels were quantified according to the manufacturers' instructions.
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Presented at the Annual Meeting of the Association for Academic Surgery, Houston, TX, November 14–17, 1990.
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Supported in part by grants from the Hebrew University and Hadassah Joint Research Fund and the Chief Scientist of the Israel Ministry of Health.