Acid ribonuclease activation in the chick oviduck by tissue damage, actinomycin D and progesterone

doi:10.1016/0022-4731(79)90515-6

Journal of Steroid Biochemistry

Volume 10, Issue 6, June 1979, Pages 629-631

https://doi.org/10.1016/0022-4731(79)90515-6 Get rights and content

Abstract

A low acid RNase activity was found in the nuclear and cytoplasmic fraction of the immature chick oviduct. The most rapid induction of cytoplasmic RNase was caused by oviductal ligation at 2 h, whereas actinomycin D and progesterone effects on RNase appeared at 10 and 24 h after administration. Nuclear acid RNase activity was much lower and increased concomitantly with the cytoplasmic RNase except for the progesterone-treated oviducts. This indicates that nuclear acid RNase may be a cytoplasmic contamination. The lysosomal origin of this acid RNase and its possible role in avidin induction is discussed.

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Structure-function relationships of acid ribonucleases: Lysosomal, vacuolar, and periplasmic enzymes
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It is surprising that only relatively recently has attention been directed to the characterization of the properties of acid ribonucleases (RNases), leading to some understanding of their biochemistry and their functional roles. The present review summarizes current progress in this field under the following general topics: (1) the wide distribution of acid RNases in organisms from viruses to animals; (2) recent findings concerning their primary and three-dimensional structure; (3) the structure-function relationship of acid RNases, with a fungal RNase from Rhizopus niveus as a model enzyme; (4) the unique localization of acid RNases in the periplasm of bacteria, vacuoles in plants, and lysosomes of animals and protozoa; and (5) the diversity of physiological roles, depending on the organism, such as self-incompatibility factors and defense proteins in some plants, the surface protein of an animal virus related to pathogenicity, and possible relationship to human cancer.
Lysosomal functions in cellular activation: Propagation of the actions of hormones and other effectors
1984, International Review of Cytology
This chapter evaluates the aspects of the individual steps in the staging of vectorial pathway and assesses their potential metabolic consequences in the processing and execution of information delivered by agonist. The chapter determines from the analysis an array of effectors and target cells as possible, whether such a pattern is generalized or unique to only certain classes of effectors or target cells. The independent data and the implications of lysosomal function in propagation and coordination of transcellular events are also considered. The integration of information is derived from the analysis of interlocking problems that contributes to the understanding of critical molecular events associated with triggering of cellular responses to tropic hormones and other effectors.
Effects of cycloheximide and streptolydigin on avidin induction in the chick oviduct
1980, Comparative Biochemistry and Physiology. Part C, Comparative
1. Cycloheximide (0.1–2 mg/kg) caused a dose-dependent inhibition of avidin induced by progesterone in the oestrogen-primed immature chick oviduct. In contrast, this inhibitor of protein synthesis had no significant effect on tissue damage-induced avidin.
2. Streptolydigin, an inhibitor of RNA-polymerase, (0.5–10 mg/kg) did not affect avidin induced by progesterone or tissue damage.
3. The lethal doses of cycloheximide and streptolydigin in the chick were respectively 2 mg/kg and 10 mg/kg of body weight.
4. The results indicate that new protein synthesis is required for avidin induction by progesterone and that this is insensitive to the RNA-polymerase inhibitor streptolydigin. The mechanism of avidin induction by tissue damage remains unsolved.
Nuclear Poly(A) Polymerase Activities in the Rabbit Uterus: Regulation by Progesterone Administration and Relation to the Activities of RNA Polymerases and Chromatin Template
1979, European Journal of Biochemistry

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Acid ribonuclease activation in the chick oviduck by tissue damage, actinomycin D and progesterone

Abstract

Rec. Progr. Horm. Res.

Molec. Cell. Endocr.

J. steroid Biochem.

Functions of lysosomes

Ann. Rev. Phys.

The lysosome as a mediator of hormone action

Rec. Progr. Horm. Res.