Journal of Molecular Biology
Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons
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Histidinol dehydrogenase
2023, Metalloenzymes: From Bench to BedsideExploring the role of the histidine biosynthetic hisF gene in cellular metabolism and in the evolution of (ancestral) genes: from LUCA to the extant (micro)organisms
2020, Microbiological ResearchCitation Excerpt :Moreover, this pathway plays an important role in cellular metabolism, being interconnected to (at least) the nitrogen metabolism and the de novo synthesis of purines (Fani et al., 2007). The biosynthetic pathway, the genetic organization, and the flux of intermediates show similar features in E. coli and S. typhimurium: in these microorganisms the eight biosynthetic genes are clustered in a compact operon (hisGDC[NB]HAF[IE]) (Carlomagno et al., 1988). Three of the his genes code for bifunctional enzymes (i.e.hisNB, hisD and hisIE), while another enzyme is heterodimeric, being composed of the hisF and hisH gene products (Alifano et al., 1996).
Independent component analysis of E. coli's transcriptome reveals the cellular processes that respond to heterologous gene expression
2020, Metabolic EngineeringCitation Excerpt :The His-tRNA iModulon consists of genes in the histidine biosynthetic pathway in the histidine operon (hisA, hisB, hisC, hisD, hisF, hisG, and hisI). Transcription of the histidine regulon is regulated by an attenuation mechanism whereby low levels of charged his-tRNA result in translational stalling along the histidine leader peptide, preventing formation of a rho-independent terminator and allowing the transcription of the rest of the operon (Carlomagno et al., 1988). This mechanism effectively couples synthesis of the histidine biosynthesis genes directly to available levels of histidine in the host, reducing overproduction and waste of cellular resources.
Origin and evolution of metabolic pathways
2009, Physics of Life ReviewsCitation Excerpt :In all histidine-synthesizing organisms the pathway is unbranched and includes several unusual reactions. Moreover, it consists of nine intermediates and of eight distinct proteins that are encoded by eight genes, hisGDC(NB)HAF(IE) with three of them (hisD, hisNB, and hisIE) coding for bifunctional enzymes (Fig. 13) [95,96]. In the two enterobacteria, the eight genes are arranged in a compact operon (Fig. 14).
Establishment of an mRNA Gradient Depends on the Promoter: An Investigation of Polarity in Gene Expression
2008, Journal of Molecular BiologyStructural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway
2006, Journal of Biological Chemistry