Research paperEffect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia☆
References (22)
- et al.
Metabolism of beta-sitosterol in man
J. Clin. Invest.
(1970) Absorbability of beta-sitosterol
Trans. N.Y. Acad. Sci.
(1955)- et al.
Absorbability of beta-sitosterol in humans
Metabolism
(1969) - et al.
Response of serum lipids and lipoproteins of man to beta-sitosterol and safflower oil — A long term study
Circulation
(1958) - et al.
Plant sterols as cholesterol-lowering agents — Clinical trials in patients with hypercholesterolemia and studies on sterol balance
Atherosclerosis
(1977) - et al.
Sitosterin bei familärer Hyperlipoproteinämie Typ II — Eine ran domisierte gekreutze Doppelblindstudie
Dtsch. Med Wschr.
(1976) - et al.
Dosiswirksamkeit von beta-Sitosterin bei Hypercholesterinaemien der Typen IIa und IIb
Münch. Med. Wschr.
(1978) - et al.
The interaction of cholesterol absorption and cholesterol synthesis in man
J. Lipid Res.
(1969) - et al.
Effects of plant sterols on cholesterol metabolism in man
Atherosclerosis
(1976) - et al.
Comparison of absorption and metabolism of beta-sitosterol and beta-sitostanol in rats
Atherosclerosis
(1978)
Intestinal absorption and lymphatic transport of cholesterol and beta-sitostanol in the rat
J. Lipid. Res.
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Phytosterols and phytostanols
2018, Encyclopedia of Food ChemistryRelative roles of ABCG5/ABCG8 in liver and intestine
2015, Journal of Lipid ResearchFunctional foods and cardiometabolic diseases. International Task Force for Prevention of Cardiometabolic Diseases.
2014, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :Lees et al. tested a commercial preparation derived from soybean oil (3 g/d) and observed a significant decrease in LDLc after consumption of this preparation [118]. Nine years later, in 1986, Heinemann et al. reported the first description of the use of plant stanols to lower plasma cholesterol [119]. These investigators showed that dispersed sitostanol in sunflower oil at a dose of 1.5 g/day lowered LDLc by 15% in hypercholesterolaemic adults.
Recomendations for clinical use of food enriched phytosterols/phytostanols handling hypercholesterolemia
2014, Clinica e Investigacion en ArteriosclerosisChemical and microbiological considerations of phytosterols and their relative efficacies in functional foods for the lowering of serum cholesterol levels in humans: A review
2014, Journal of Functional FoodsCitation Excerpt :In consideration of these fundamentals, stanol (of identical internal composition) at equi-molar quantities would be substantially more efficacious than stanol ester (of identical internal composition) in the lowering of serum cholesterol levels. The supporting evidence for this proposition was the first reported clinical trial of stanols on humans made in Germany more than 25 years ago (Heinemann, Leiss, & von Bergmann, 1986). Stanols have subsequently been reported further to be exceptionally efficacious in lowering cholesterol levels of adults (Heinemann, Küllak-Ublick, Pietrück, & von Bergmann, 1991) and children (Becker, Stabb, & von Bergmann, 1993; Gylling, Siimes, & Miettinen, 1995; Williams, Bollella, Strobino, Boccia, & Campanaro, 1999).
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
2021, Frontiers in Pharmacology
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This work was supported in part by the Sandoz Stiftung für therapeutische Forschung and Deutsche Forschungsgemeinschaft (Le 385/3-1).