Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride

doi:10.1016/0021-9150(85)90105-4

Atherosclerosis

Volume 55, Issue 3, June 1985, Pages 259-266

https://doi.org/10.1016/0021-9150(85)90105-4 Get rights and content

Abstract

Increased plasma insulin and triglycerides and decreased high density lipoprotein concentrations are primary risk factors in the development of coronary artery disease. The aim of the present study was to verify whether there was an independent relationship between plasma insulin levels and both HDL cholesterol and triglyceride in a worker population of 607 subjects, 389 men and 218 women, aged 23–73 years. An oral glucose tolerance test (75 g) was performed. Plasma glucose, insulin, triglyceride and HDL cholesterol were measured at fasting, plasma glucose and insulin were determined also 1 h and 2 h after glucose load. The results, examined separately in men and women documented a significant negative relationship between plasma insulin and HDL cholesterol level, as well as pointing out that both HDL cholesterol and insulin are significantly correlated to degree of hypertriglyceridemia, degree of obesity and level of glucose tolerance. The partial correlation coefficients between HDL cholesterol and plasma insulin levels at fasting in men and post-glucose load in women, demonstrated an independent relationship between increased plasma insulin and decreased plasma HDL concentration. However, the strongest relationship, revealed by partial correlation coefficient analysis, was between the degree of hyperinsulinemia and hypertriglyceridemia.

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Research paperEvidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride

Abstract

Amer. J. Med.

Atherosclerosis

Atherosclerosis

Atherosclerosis

Amer. J. Med.

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle aged population

Diabetologia

Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease — Results from two population studies in Finland

Diabetes Care

Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations

Diabetes Care

Plasma triglycerides in regulation of HDL cholesterol levels

Lancet

High density lipoprotein and other lipoproteins in normolipidaemic and hypertriglyceridaemic (type IV) men with coronary artery disease

Europ. J. Clin. Invest.

High density lipoprotein metabolism in man

J. Clin. Invest.

Role of insulin in endogenous hypertriglyceridemia

J. Clin. Invest.

Research paper
Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride