An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection
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Cited by (133)
Identification of the amino acids in the Major Histocompatibility Complex class II region of Scottish Blackface sheep that are associated with resistance to nematode infection
2019, International Journal for ParasitologyCitation Excerpt :General and generalised linear models are valuable for the analysis of data in livestock because they allow the influence of factors such as year, sex, sire and dam to be taken into account. Studies by us and others have shown that the DRB1*11:01 allele is associated with reduced egg counts in Scottish Blackface (Schwaiger et al., 1995; Stear et al., 2005) as well as Texel (Ali et al., 2019) and Suffolk sheep (Sayers et al., 2005). In addition, the same allele is associated with reduced numbers of adult T. circumcincta following both deliberate and natural infection (Stear, M.J., Abuargob, O., Ben Othman, M., Bishop, S.C., 2006.
Ovar-DRB1 haplotypes *2001 and *0301 are associated with sheep growth and ewe lifetime prolificacy
2016, GeneCitation Excerpt :Among sheep MHC class II genes, the DRB1 and DQB1 loci have been found to be highly polymorphic and this polymorphism is maintained by a form of balancing selection (Hughes and Yeager, 1998). In particular, exon 2 encodes the highly polymorphic antigen-binding site (Herrmann-Hoesing et al., 2008) where 106 Ovar-DRB1 separate alleles have been identified (Ballingall et al., 1992; Fabb et al., 1993; Schwaiger et al., 1995; Kostia et al., 1998; Paterson, 1998; Nagaoka et al., 1999; Jugo and Vicario, 2000; Konnai et al., 2003a; Herrmann-Hoesing et al., 2008). Variation in the Ovar-DRB1 gene may impact immune responses to pathogens, which may lead to variation in disease resistance.
Genomic Regions Associated with Sheep Resistance to Gastrointestinal Nematodes
2016, Trends in ParasitologyThe Immune Response to Nematode Infection
2023, International Journal of Molecular SciencesGenome-wide association study in thoroughbred horses naturally infected with cyathostomins
2023, Animal Biotechnology
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The contribution of the first two authors was equal.