Protection by gastrin in the rat stomach involves afferent neurons, calcitonin gene-related peptide, and nitric oxide☆,☆☆
References (43)
- et al.
Pentagastrin protects against stress ulceration in rats
Gastroenterology
(1979) - et al.
Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin
Eur J Pharmacol
(1994) - et al.
Afferent nerve-mediated protection against deep mucosal damage in the rat stomach
Gastroenterology
(1990) - et al.
Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury
Gastroenterology
(1991) - et al.
Impaired defense mechanism to peptic ulcer in the capsaicin-desensitized rat
- et al.
Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin
Gastroenterology
(1993) - et al.
A role of nitric oxide in capsaicin-induced gastroprotection
Eur J Pharmacol
(1991) - et al.
Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach
Neurosci Lett
(1990) - et al.
Differential effect on neuropeptide release of different concentrations of hydrogen ions on afferent and intrinsic neurons of the rat stomach
Gastroenterology
(1991) - et al.
The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
Eur J Pharmacol
(1989)
Endogenous nitric oxide as a mediator of gastric mucosal vasodilation during acid secretion
Gastroenterology
Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons
Gastroenterology
Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat
Neuroscience
A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection
Eur J Pharmacol
Neurochemical evidence of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) release from capsaicin-sensitive nerves in rat mesenteric arteries and veins
Gen Pharmacol
Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery
Biochem Biophys Res Commun
Calcitonin gene-related peptide-α receptor binding sites in the gastrointestinal tract
Neuroscience
Effects of in vivo stimulation on molecular forms of circulatory calcitonin and calcitonin gene-related peptide in man
Mol Cell Endocrinol
Afferent nerve-mediated protection against deep mucosal damage in the rat stomach
Gastroenterology
Effect of capsaicin on gastric mucosal injury and blood flow following bile acid exposure
J Surg Res
Cytoprotective effect of pentagastrin and epidermal growth factor on stress ulcer formation
Ann Surg
Cited by (62)
Gastric complications of drug treatments
2016, Medicine (Spain)New satiety hormone nesfatin-1 protects gastric mucosa against stress-induced injury: Mechanistic roles of prostaglandins, nitric oxide, sensory nerves and vanilloid receptors
2013, PeptidesCitation Excerpt :NO, which plays a crucial role in the mechanism of gastroduodenal defense, could be released from the vascular endothelium, sensory nerves or gastric epithelial cells [54], and therefore, we hypothesized that nesfatin-1-induced gastroprotection may involve NO originating from the activation of capsaicin-sensitive afferent sensory neurons. Moreover, PG were found to cooperate with NO and sensory nerves in the mechanism of gastric mucosal integrity and cytoprotection [37,50]. In our present study, capsaicin denervation exacerbated WRS-induced gastric lesions and also significantly reduced the GBF when compared to those with intact sensory nerves.
CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells
2012, Molecular and Cellular EndocrinologyGastric mucosal defense and cytoprotection
2010, Best Practice and Research: Clinical GastroenterologyGastric Mucosal Defense and Cytoprotection: Bench to Bedside
2008, GastroenterologyCitation Excerpt :Hydrogen sulfide is another endogenously generated compound that exerts a strong mucosal protective action similar to NO; it reduces tumor necrosis factor α (TNF-α) expression, decreases leukocyte adherence to vascular endothelium, and inhibits NSAID-induced gastric mucosal injury.46,47 Gastric mucosa and submucosal vessels are innervated by primary afferent sensory neurons and nerves forming a dense plexus at the mucosal base (Figure 3A).45,48,49,50 The nerves fibers from this plexus enter the lamina propria (accompanying capillary vessels) and end just beneath the surface epithelial cells (Figure 3B).
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Supported by grant Pe-215/6 from the Deutsche Forschungsgemeinschaft.
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Presented in part at the 1994 annual meeting of the American Gastroenterological Association in New Orleans, Louisiana, and published in abstract form (Gastroenterology 1994; 106:A186).