Regular articleNucleolin is an Ag-NOR protein; This property is determined by its amino-terminal domain independently of its phosphorylation state☆
References (64)
- et al.
Exp. Cell Res
(1989) - et al.
Life Sci
(1979) - et al.
Exp. Cell Res
(1986) - et al.
Exp. Cell Res
(1982) - et al.
Exp. Cell Res
(1985) - et al.
Biol. Cell
(1989) - et al.
J. Biol. Chem
(1987) - et al.
Biochim. Biophys. Acta
(1984) - et al.
J. Biol. Chem
(1985) - et al.
J. Biol. Chem
(1987)
FEBS Lett
Cell Biol. Intern. Rep
Exp. Cell Res
Exp. Cell Res
Cell Biol. Intern. Rep
FEBS Lett
J. Biol. Chem
Biochem. Biophys. Res. Commun
Cell
Biochem. Cell Biol
Lab. Invest
J. Histochem. Cytochem
J. Cell Sci
Chromosoma
J. Cell Sci
Chromosoma
Cancer
Int. Rev. Exp. Pathol
Chromosoma
J. Histochem. Cytochem
Development
Cited by (81)
Nucleolin: Dual roles in rDNA chromatin transcription
2015, GeneCitation Excerpt :Now, the name of nucleolin is widely used for this nucleolar protein. Furthermore, it was detected by silver staining as it is an Ag-NOR (silver stained-Nucleolar Organizer Region) protein (Goodpasture and Bloom, 1975; Fernandez-Gomez et al., 1983; Roussel et al., 1992). Interestingly, Ag-staining is observed in NORs displaying secondary constrictions (transcriptionally active) but not in NOR lacking these constrictions (transcriptionally inactive) (Hernandez-Verdun et al., 1982; Lacadena et al., 1984; Haasen et al., 1999).
Quantitative analysis of AgNOR proteins in buccal epithelial cells of Indian street boys addicted to gasp 'golden glue'
2011, Experimental and Toxicologic PathologyCitation Excerpt :As a cytochemical technique, AgNOR is not specific for a single protein. Instead, it reveals several silver affinity proteins belonging to ribosome assembly machinery (Roussel et al., 1992). In interphase cells, nucleolin and nucleophosmin are the two most important AgNOR proteins (Derenzini et al., 2000).
AgNOR status in Down's syndrome infants and a plausible phenotype formation hypothesis
2009, MicronCitation Excerpt :Moreover, in cancer tissues, AgNOR-protein expression was found to be strictly related to the cell duplication rate (Trerè, 2000). Using a purified protein, Western blots, AgNOR-staining and immunological characterization, Roussel et al. (1992) revealed nucleolin to be the first AgNOR-protein. They proposed that the concentration of acidic amino acids in the amino-terminal domain of nucleolin is responsible for AgNOR staining.
Cleavage of nucleolin and argyrophilic nucleolar organizer region associated proteins in apoptosis-induced cells
2003, Biochemical and Biophysical Research CommunicationsAbnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: A novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis
2001, BloodCitation Excerpt :The structural component of NORs is mainly constituted by 2 multifunctional proteins: the C23 or nucleolin, 110 kd,26,27 and the B23 or nucleophosmin, 39 kd.28–30 NOR-associated proteins, whose abundance,31–33 turnover,34–40 and localization41–44 are closely linked to ribosomal gene activity, are usually called “AgNOR” because of their argyrophilic property. Their pattern of expression has been studied in normal and neoplastic tissues,45,46 with the aim of assessing cell kinetics parameters such as the percentage of cycling cells and time of cell replication.
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This project was supported by grants from the CNRS, FRM, ARC (Contrat 6703), INSERM and from the Science Programme of the Commission of the European Communities (SC1-O259-C).