Spermine prevents endonuclease activation and apoptosis in thymocytes☆
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Cited by (194)
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2
2021, Molecular CellCitation Excerpt :Polyamines are essential organic compounds for maintaining various biological activities in all eukaryotes (Tabor and Tabor, 1984; Marton and Pegg, 1995). Among the various polyamine species, spermine (SPM) plays especially important roles in cells, such as interacting with nucleic acids to regulate transcriptional activity (Kanemura et al., 2018), stabilizing chromatin structure (Snyder, 1989; Feuerstein et al., 1990), and protecting DNA (Brüne et al., 1991; Khan et al., 1992a, 1992b). In addition, intracellular SPM protects cells from damage caused by reactive oxygen species (ROS) (Ha et al., 1998; Li et al., 2017).
Characterization of arginase expression by equine neutrophils
2014, Veterinary Immunology and ImmunopathologyCitation Excerpt :These results suggest that arginase regulates a yet unknown mechanism that is triggered rapidly during the course of LPS/fMLP-induced apoptosis. The regulation of apoptosis by the arginase pathway may involve spermine through chromatin stabilization and prevention of endonuclease activation (Brune et al., 1991) as well as earlier processes such as the control of reactive oxygen species production by downstream enzymes or products of the arginase pathway such as ODC (Liu et al., 2005) and spermine (Ogata et al., 1992, 1996). In conclusion, this study demonstrated that equine neutrophils constitutively express arginase similarly to human neutrophils, although the isoform 2 was exclusively expressed by equine neutrophils in contrast to human neutrophils which express the arginase I isoform only.
Highly selective colorimetric detection of spermine in biosamples on basis of the non-crosslinking aggregation of ssDNA-capped gold nanoparticles
2013, TalantaCitation Excerpt :The naturally occurring spermine (Spm), as one of many cationic polyamines, exists in all eukaryotic cells and plays important roles in cell growth and differentiation [1–3], including the regulation of gene expression [3], the stabilization of chromatin [4], the prevention of endonuclease-mediated DNA fragmentation [5], and the inhibition of DNA damage [6,7].
Molecular Mechanisms of Toxic Cell Death: An Overview
2013, In Vitro Toxicity IndicatorsA stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on concentration
2011, BiochimieCitation Excerpt :As the ubiquitous cellular constituents, natural polyamines such as spermine (SPM), spermidine (SPMD) and putrescine (PTS) (Fig. 1) should be given particular attention because they are highly charged with high millimolar concentrations in cells at physiological pH [32]. Moreover, these natural polyamines had been proved to exhibit important biological functions in cell differentiations, proliferation, and apoptosis [33–35]. In some tumor cells, polyamines are found to be in higher concentrations than those in normal cells, suggesting polyamine metabolism and function also are in correlation with tumor growth and proliferation [36–38].
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This study was supported by grants from the Swedish Medical Research Council (Proj. No. 03X-2471) and the Deutsche Forschung Gemeinschaft (to B. Brüne).
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Present Address: Universität Konstanz. Fakultät für Biologie. Universitätsstrasse 10. Postfach 5560, D-7750 Konstanz. Germany.