Short noteGlutathione content and growth in A549 human lung carcinoma cells☆
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2017, International Journal of PharmaceuticsCitation Excerpt :Whilst the ischemia may kill many of the tumour cells, some may survive within this hypoxic milieu and are known to become chemoresistant and secrete growth factors that promote angiogenesis and metastasis of tumour cells to other parts of the body (Kunz and Ibrahim, 2003). Hypoxic tumour cells have been shown to overexpress intracellular glutathione (GSH) (Kuppusamy et al., 2002) which has been associated with enhanced cellular proliferation (Kang and Enger, 1990), reduced apoptosis (Hall, 1999) and increased resistance to chemotherapy (Traverso et al., 2013). The associated increase in reducing potential compared to normal tissue however, has been used to target tumour cells intracellularly using a variety of redox-responsive nanocarriers such as dendrimers (Kurtoglu et al., 2009), micelles (Lv et al., 2014), polymersomes (Nahire et al., 2014) and liposomes (Sun et al., 2015).
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This work was supported by NIEHS/PHS Grant ESO3863-02 and by Iowa State University.