Short communicationDuration-dependent increase in striatal glutamate following prolonged fluphenazine administration in rats
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2003, Neuroscience and Biobehavioral ReviewsMotor cortical excitability in schizophrenia
2002, Biological PsychiatryCitation Excerpt :In addition, we found an increase in intracortical facilitation that might be related to glutamatergic effects or may be secondary to the reduced cortico-cortical inhibition. Conventional antipsychotic agents have complex effects on glutamatergic activity (Goff 2000) including enhanced release of glutamate in striatum (Yamamoto and Cooperman 1994; See and Lynch 1996), direct agonist effects on glutamatergic N-methyl-D-aspartate receptors (Banerjee et al 1995; Fletcher and MacDonald 1993; McCoy and Richfield 1996) and antipsychotics can alter the subunit composition of glutamatergic receptors (Fitzgerald et al 1995; Healy and Meador-Woodruff 1997; Meador-Woodruff et al 1996; Riva et al 1997). Each of these effects on glutamate release or receptor dynamics might affect cortical activation, either at the level of pyramidal neurons or inhibitory interneurons (Grunze et al 1996).
Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular γ-aminobutyric acid levels in the striatum
2002, Biochemical PharmacologyCitation Excerpt :Specifically, the 15 mg/kg dose of PLZ produced a larger increase in extracellular GABA levels in the nucleus accumbens than it did in the caudate-putamen. Also, others have shown that different populations of GABA neurons exist in the dorsal and ventral striatum [30], and that the effects of various manipulations on GABA levels in dialysates collected from the caudate-putamen and nucleus accumbens are dissociable [43–46]. The present results also demonstrated that PLZ rapidly increases extracellular GABA levels.