Short communicationEffect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac
References (12)
- et al.
Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac in the rat
Eur. J. Pharmacol.
(1995) - et al.
The formalin test: an evaluation of the method
Pain
(1992) - et al.
Mechanism of diclofenac antinociception: direct blockade of inflammatory sensitization
Eur. J. Pharmacol.
(1994) Ethical guidelines for investigation on experimental pain in conscious animals
Pain
(1983)Ethics of Animal Investigation
(1989)- et al.
Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat
Can. J. Physiol. Pharmacol.
(1994)
Cited by (27)
Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway
2019, Epilepsy ResearchCitation Excerpt :In addition, the results of several studies demonstrate the modulatory role of the NO-cGMP pathway on the anticonvulsant effect of adenosine (Akula et al., 2008; Kaku et al., 2001). There is obvious evidence that caffeine can modulate NO production (Lopez-Munoz et al., 1996; Kayir and Uzbay, 2004). For example, NO production decreases as the result of A1Rs activation, whereas activation of A2ARs leads to elevation of NO generation (Bruce et al., 2002).
Tramadol and caffeine produce synergistic interactions on antinociception measured in a formalin model
2010, Pharmacology Biochemistry and BehaviorCitation Excerpt :Clinically, caffeine has been used as an adjuvant for many years, both to eliminate sleepiness induced by antihistamines and to provide better analgesic efficacy. Combinations of non-steroidal anti-inflammatory drugs (NSAIDS) with caffeine have been analyzed in different animal models; caffeine with ibuprofen, aspirin, ketorolac in pain-induced functional impairment in the rat (PIFIR model) (Medina et al., 2006; López-Muñoz et al., 1996; Castañeda-Hernández et al., 1994), paracetamol + caffeine in hot plate (Engelhardt et al., 1997) and aspirin + caffeine in carrageenan-induced edema in the hind paw test (Vinegar et al., 1976). Misra et al. (1985) reported that the antinociceptive effect of morphine was potentiated by caffeine.
Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats
2006, European Journal of PharmacologyThe NO-cGMP-K<sup>+</sup> channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin
2003, Pharmacology Biochemistry and BehaviorEffects of caffeine as an adjuvant to morphine in advanced cancer Patients: A randomized, double-blind, placebo-controlled, crossover study
2001, Journal of Pain and Symptom ManagementEffect of caffeine on antinociceptive action of ketoprofen in rats
2001, Archives of Medical Research