The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes
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Structure-activity relationship of serotonin derived tocopherol lipids
2019, International Journal of PharmaceuticsCitation Excerpt :Phenyl group of indole ring in Lipid B was shown to have π-π stacking interactions with Phe 330 and fused tetrahydropyran with Tyr 109 and 5-hydroxyl group of indole and hydroxyl group in linker was shown to have hydrogen bond interactions with Asp129 (Fig. 13C). The involvement of hydroxyl group of serotonin moiety may favor hydrogen bonding interactions with the receptor, in accordance with the reported mutational and modeling studies (Kitson, 2007; Cheng et al., 1993) where serotonin1A receptor prefers ligands with hydrogen bond acceptor at a position corresponding to the hydroxyl group in serotonin. The docking studies similarly show that Lipid B with the free hydroxyl group is available for interaction with serotonin1A receptor, (Fig. 13).
Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT<inf>1A</inf> receptors
2002, European Journal of PharmacologyThe effects of ibogaine on dopamine and serotonin transport in rat brain synaptosomes
1999, Brain Research BulletinSerotonin transporters in adult rat brain astrocytes revealed by [<sup>3</sup>H]5-HT uptake into glial plasmalemmal vesicles
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