Experimental studies on the uptake and retention of labelled proteins in a rat tumour

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Abstract

The initial uptake and later retention of labelled albumin and fibrinogen was studied in a transplantable rat tumour and compared to various normal tissues of the rat. A high uptake and retention of both proteins was found in tumour as compared to normal tissues. This mechanism is probably based on a high capillary permeability of the tumour capillary wall also for large protein molecules.

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The original research reported in this communication was supported by a grant from the Swedish Cancer Society (grant No. 72: 131).

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