Elsevier

Environmental Research

Volume 4, Issue 4, October 1971, Pages 343-354
Environmental Research

Effect of ozone on elastic behavior of excised lungs of dogs

https://doi.org/10.1016/0013-9351(71)90033-8Get rights and content

Abstract

We measured the static, deflation VP behavior of excised paired lobes of dogs' lungs before and after ventilation with either air or ozone (6.8–10.3 ppm × 2.5 hours). The lobes exposed to ozone showed only a slight increase in recoiling force at intermediate and large volumes and a more rapid fall in dynamic compliance compared with lobes exposed to air. We exposed additional excised lobes to air or ozone (4.3–10.0 ppm × 2.5 hours) during ventilation characterized by a large tidal volume, slow frequency (9–10 cycles/minute) and end-expiratory collapse (distending pressure about 1 cm H2O): both groups showed similar impairment of alveolar stability and, following continuous inflation for several hours at 10–15 cm H2O), similar degrees of recovery. It is uncertain to what extent the results reflected changes in surface active material and/or tissue elasticity. Nonetheless, any direct interaction between ozone and either of these elements would appear to play a subordinate role in the appreciable changes in elastic behavior of the lungs that many accompany acute exposure to the gas in vivo.

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