Full paperFunctional implications of the unusual spatial distribution of a minor α-tubulin isotype in Drosophila: A common thread among chordotonal ligaments, developing muscle, and testis cyst cells☆
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A Change in ECM Composition Affects Sensory Organ Mechanics and Function
2019, Cell ReportsCitation Excerpt :The model predicts that the observed phenotypes could result from reduced cap cell bending rigidity and increased ECM stiffness as a result of the ECM compositional change. The cytoskeleton of the ChO cap cell consists mainly of microtubules (Dettman et al., 2001; Matthews et al., 1990), whereas actin is present mainly at the ECM adhesion sites (Figure S7). The bending rigidity of the cap cell can be reduced as a result of a change in the mechanical properties of the microtubules.
A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons
2016, Developmental BiologyCitation Excerpt :Each of the five scolopidia that constitute the LCh5 organ contains a sensory unit composed of a neuron and a scolopale cell, and two accessory cells between which the sensory unit is stretched: a cap cell at the dendritic side and a ligament cell at the axonal side of the neuron. The cap and the ligament cells of all five organs are anchored to the cuticle by two cap-attachment (CA) cells (Ghysen and Dambly-Chaudiere, 1989; Matthews et al., 1990) and one ligament-attachment cell (LA), respectively (Inbal et al., 2004) (Fig. 1). The neuron, scolopale, cap, ligament and CA cells of each scolopidium are derived from a single Ato-expressing precursor through four asymmetric cell divisions (Brewster and Bodmer, 1995; Jarman et al., 1993).
The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe
2010, Developmental BiologyCitation Excerpt :Altogether these observations strongly suggest that Sr plays an important role in terminal differentiation of ligament cell. It has been previously suggested that α-Tub85E, which is expressed in the testis, certain muscles and Ch organs, is required for the ability of these cells to elongate (Matthews et al., 1990). Moreover, mutations in α-Tubulin cause defects in neural migration in mice and lissencephaly in humans (Keays et al., 2007).
Analysis of α- and β-tubulin genes of Bombyx mori using an EST database
2003, Insect Biochemistry and Molecular Biology
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This work was supported by NSF BSR-8742084.