Therapeutic abortion in early pregnancy with antiprogestogen RU486 alone or in combination with prostaglandin analogue (Gemeprost)
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Cited by (113)
The endometrial response to modulation of ligand-progesterone receptor pathways is reversible
2021, Fertility and SterilityContinuing pregnancy after mifepristone and "reversal" of first-trimester medical abortion: A systematic review
2015, ContraceptionCitation Excerpt :If we assume that the patient lost to follow-up had an abortion, the continuing pregnancy proportion was 57% (95% CI 25–84%). Our search retrieved 1115 unduplicated articles, and 13 studies in 11 publications met our inclusion criteria (one publication was an English-language article that included two relevant studies performed in China, and one publication provided complete information on two relevant mifepristone dosages) (Fig. 2) [8–18]. Women were generally assessed 1–2 weeks after mifepristone and those with a continuing pregnancy at that time underwent surgical abortion.
A pilot study on the use of a 7-day course of letrozole followed by misoprostol for the termination of early pregnancy up to 63 days
2012, ContraceptionCitation Excerpt :The most widely used regimen for medical abortion of pregnancy up to 63 days involves the use of oral mifepristone 200 mg followed by vaginal misoprostol 800 mcg 24–48 h later. The complete abortion rate is up to 95% [3–5], approaching that of surgical abortions [17]. However, mifepristone is expensive and is only available in 44 countries [18].
Mifepristone (RU 486) induces vasodilation and inhibits platelet aggregation: Nongenomic and genomic action to cause hemorrhage
2011, ContraceptionCitation Excerpt :The synthetic steroid mifepristone (RU 486; trade name Mifeprex), with antiprogesterone and antiglucocorticoid activities, has been approved in several countries for use in four indications: (i) early termination of pregnancy (TOP), (ii) cervical dilatation prior to surgical TOP, (iii) preparation for prostaglandin-induced TOP during the second-trimester and (iv) expulsion of dead fetus during the third-trimester (for review, see Ref. [1]). Regarding the first indication, a number of experimental studies have clearly documented that use of the combined treatment with mifepristone and a prostaglandin analogue (gemeprost or misoprostol) is highly effective for TOP [2–7]. At present, since 2000, mifepristone/misoprostol is the only approved regimen by the Food and Drug Administration (FDA).
Pain during medical abortion: Predicting factors from gynecologic history and medical staff evaluation of severity
2011, ContraceptionCitation Excerpt :Mifepristone and prostaglandin analogues are widely used to induce medical abortion in early pregnancy [1–3].
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Present address: Department of Obstetrics and Gynaecology Monash University Queen Victoria Medical Centre 172 Lonsdale Street Melbourne, Australia, 3000.