Increases in tissue levels of ubiquinone in association with peroxisome proliferation
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Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane
2018, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :In the present study we have investigated the effect of ubiquinone on the lipid packing and barrier properties of membranes with a lipid composition resembling that of the inner mitochondrial membrane (IMM). A relevant feature of the IMM, which typically contains Q10 in comparably large proportions (0.5–2 mol%, related to the lipid content [23,24]), is the high content (~49 mol%) of phosphoethanolamine (PE) lipids, as well as the presence of substantial proportions (~6 mol%) of cardiolipin (CL) [25]. It is plausible that the presence of these lipids could have an important influence on the Q10-membrane interactions.
Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
2015, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :It can be speculated that this function of Q10 would be of particular importance in the cholesterol-poor mitochondrial membranes. It is in this context interesting to note that the Q10 content in mitochondrial membranes is about 0.5–2 mol% with respect to the lipid content [67,68] and thus close to the content in the liposomes investigated in the present study. It needs to be considered, however, that ~ 20 mol% of the total lipid-associated phosphorous in the mitochondrial membranes is contributed by cardiolipins [69], which are structurally substantially different from the phosphocholines employed in the current study.
Increased muscle coenzyme Q10 in riboflavin responsive MADD with ETFDH gene mutations due to secondary mitochondrial proliferation
2013, Molecular Genetics and MetabolismCitation Excerpt :But given the facts that the protein expression of mitochondrial marker, citrate synthase, was elevated and mtDNA copy number in muscle was increased, there must be mitochondrial proliferation in these MADD patients. Since CoQ10 is synthesized in the inner membrane of mitochondria and is mainly distributed in mitochondria [13], the proliferation of mitochondria should be considered as a possible cause of increased CoQ10 levels. Citrate synthase, that catalyzes the first and rate-limiting step of the Krebs cycle, is commonly used as a quantitative marker of intact mitochondrial mass.
Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
2011, Free Radical Biology and MedicineMetabolism and function of coenzyme Q
2004, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :In humans there is also an induction of some peroxisomal enzymes but no increase in the number of peroxisomes [250]. When rodents are treated with peroxisomal inducers, CoQ amount increases in various organs [251,252]. Among the most effective inducers in rat is the plasticizer di(ethylhexyl)phthalate (DEHP), which after 6 weeks of administration in the diet increases CoQ amount in the liver by five times (Fig. 11).