An experimental study on the effect of nifedipine on ischaemic skin flap survival in rats

doi:10.1016/0007-1226(91)90076-V

British Journal of Plastic Surgery

Volume 44, Issue 4, 1991, Pages 299-301

https://doi.org/10.1016/0007-1226(91)90076-V Get rights and content

Abstract

Vasodilators have been employed previously in an attempt to improve survival of ischaemic rat skin flaps. The effect of nifedipine, a calcium channel blocker, on skin flap survival was studied using a standard experimental rat model. The control group had a mean flap necrosis of 37.009%. Rats treated by nifedipine starting 1 day preoperatively and continued for 1 week postoperatively had a mean necrosis of 10.0953%. Rats treated by nifedipine started postoperatively and continued for 1 week had a mean flap necrosis of 12.289%. Treated groups had significantly lower flap necrosis in comparison to untreated controls. There was no significant difference in flap necrosis between the two treated groups. This study shows that nifedipine improves survival in standard ischaemic rat skin flaps.

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An experimental study on the effect of nifedipine on ischaemic skin flap survival in rats

Abstract

European Journal of Pharmacology

British Journal of Plastic Surgery

Journal of Surgical Research

Interaction between nifedipine and postsynaptic alpha 1 and alpha 2 adrenoceptors following oral pretreatment of spontaneously hypertensive rats

Journal of Cardiovascular Pharmacology

The effect of nifedipine on skin flap survival

Plastic and Reconstructive Surgery

Prevention of skin flap necrosis by a course of treatment with vasodilator drugs

Plastic and Reconstructive Surgery

Basic and Clinical Pharmacology

Pharmacologic treatment of failing skin flap

Plastic and Reconstructive Surgery