Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids

doi:10.1016/0006-8993(96)00990-0

Brain Research

Volume 738, Issue 1, 28 October 1996, Pages 154-157

https://doi.org/10.1016/0006-8993(96)00990-0 Get rights and content

Abstract

The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 μM) completely suppressed epileptiform activity induced by omission of Mg²⁺ as well as normal neuronal activity, whereas lappaconitine (10 μM) and 6-benzoylheteratisine (10 μM) diminished epileptiform activity by sparing normal neuronal activity.

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Short communicationInhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids

Abstract

Neuropharmacology

Brain Res.

J. Ethnopharmacol.

Neurosci. Lett.

Trends Pharmacol. Sci.

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes

Annu. Rev. Pharmacol. Toxicol.

Cellular and molecular biology of voltage-gated sodium channels

Physiol. Rev.

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons

Mol. Pharmacol.

Electrophysiological actions of phenytoin on N-methyl-D-aspartate receptor-mediated responses in rat hippocampus in vitro

Br. J. Pharmacol.

Short communication
Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids