Short communicationMagnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast agent☆
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Enabling biodegradable functional biomaterials for the management of neurological disorders
2019, Advanced Drug Delivery ReviewsCitation Excerpt :To improve the in vivo circulating time and biocompatibility of MRI contrast agents, biodegradable polymer encapsulated magnetic nanoparticles have been fabricated. Norman et al. developed wheat germ agglutinin coated magnetite nanoparticles, and used them for neural stem cell labeling [162]. Furthermore, Granot et al. prepared biodegradable magnetic PLGA nanoparticles (~100 nm) and microparticles (1-2 μm) for MRI-based cell tracking.
Stimuli-responsive magnetic particles for biomedical applications
2011, International Journal of PharmaceuticsCitation Excerpt :For this purpose, MRI needs to be non-invasive. An example of this study is the use of cellular tagging of fetal cells using wheat germ agglutin (WGA)-conjugated magnetic particles (Norman et al., 1992) or reconstituted Sendai virus enveloped containing magnetite (Hawrylak et al., 1993) followed by cerebral implantation and serial MRI for up to two months. This system allows the monitoring of in vivo cell migration in neural grafting procedures.
Magnetic Resonance Labeling of Stem Cells. Is Positive Tracking a Plus or a Minus?
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2008, Colloids and Surfaces A: Physicochemical and Engineering AspectsMRI Contrast Agents in Glycobiology
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Supported by National Science Foundation Grant BNS 9015373.
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We are grateful to Advanced Magnetics Inc. for donating the WGA-ferrite particles and providing useful technical information. We would like to thank Jennifer M. Klug and Wayne Ouellette for excellent technical assistance. We would also like to thank Mel Fariello for manuscript preparation.