Elsevier

Brain Research

Volume 496, Issues 1–2, 4 September 1989, Pages 180-186
Brain Research

Localization of calcitonin gene-related peptide and its receptors in a striated muscle

https://doi.org/10.1016/0006-8993(89)91064-0Get rights and content

Abstract

The distribution of calcitonin gene-related peptide (CGRP) and its binding sites in the bulbocavernosus, a striated muscle, are reported. We used immunohistochemistry and [125I]CGRP autoradiography. The pattern of [125I]CGRP binding was restricted to a discrete band that coincides with the distribution of end-plates in this muscle as determined by CGRP immunohistochemistry and actylcholinesterase staining. CGRP has been shown to increase the level of acetylcholine receptor (AChR) α-subunit mRNA. The role of CGRP as the endogenous factor by which motoneurons regulate the expression of junctional AChR is discussed.

References (39)

  • AxelsonJ. et al.

    A study of supersensitivity in denervated mammalian skeletal muscle

    J. Physiol. (Lond.)

    (1957)
  • BetzH. et al.

    Regulation of muscle acetycholine receptor synthesis in vitro by cyclic nucleotide derivates

    Nature (Lond.)

    (1979)
  • BlasserJ.C. et al.

    Regulation of acetylcholine receptor by cyclic AMP

    J. Biol. Chem.

    (1980)
  • BrockesJ.P. et al.

    Acetylcholine receptors in normal and denervated rat diaphragm muscle. II. Comparison of junctional and extrajunctional receptors

    Biochemistry

    (1975)
  • BrockesJ.P. et al.

    Synthesis of acetylcholine receptor by denervated rat diaphragm muscle

  • DevreotesP.N. et al.

    Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor digitorum longus muscles

  • FontaineB. et al.

    Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor α-subunit mRNA levels by distinct intracellular pathways

    J. Cell Biol.

    (1987)
  • GibsonS.J. et al.

    Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species

    J. Neurosci.

    (1984)
  • GoltzmanD. et al.

    Interaction of calcitonin gene-related peptide at receptor sites in target tissues

    Science

    (1985)
  • Cited by (0)

    View full text