Tachyphylaxis of dipsogenic activity to intracerebroventricular administration of angiotensins
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Cited by (26)
Angiotensin II (de)sensitization: Fluid intake studies with implications for cardiovascular control
2016, Physiology and BehaviorAcute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain
2014, Brain ResearchCitation Excerpt :Repeated injections of Ang II have different effects, dependent upon the timing of the injections. Specifically, daily injections of Ang II or continuous infusion over days sensitizes its dipsogenic and natriorexigenic potencies (Bryant et al., 1980; Moellenhoff et al., 2001; Pereira et al., 2010), but acute repeated injections within a shorter timeframe desensitize the water intake response normally observed after Ang II injection (Quirk et al., 1988; Torsoni et al., 2004; ; Vento et al., 2012). Interestingly, the behavioral desensitization caused by acute repeated injections of Ang II is selective to the water intake effects of the peptide, with no observed desensitization of saline intake (Vento and Daniels, 2010a).
The anteroventral third ventricle region is critical for the behavioral desensitization caused by repeated injections of angiotensin II
2014, Behavioural Brain ResearchCitation Excerpt :Specifically, after pretreatment with losartan, rats given an AngII treatment regimen drank more water than did rats given a vehicle treatment regimen (p = 0.012). Repeated icv administration of AngII causes a reduction in water intake stimulated by an icv injection of AngII given later [11–16]. This AngII-induced behavioral desensitization is specific to the angiotensin system and not the result of a broader behavioral impairment [16].
Investigation into the specificity of angiotensin II-induced behavioral desensitization
2012, Physiology and BehaviorProlonged effects of intracerebroventricular angiotensin II on drinking, eating and locomotor behavior in mice
2012, Regulatory PeptidesCitation Excerpt :In this study, the acute effects of Ang II are consistent with previous reports showing that rapid, marked increases in water intake caused by central injection of Ang II is mediated via the AT1 receptor with an interaction with the AT2 receptor [4,20]. Others have reported that repeated ICV administration of Ang II causes a progressive decline of water consumption known as dipsogenic tachyphylaxis [21]. Our results suggest the possibility that the prolonged potent inhibitory effect of water consumption mediated by AT2 receptors would counteract the acute dipsogenic response after repeated central Ang II injection, resulting in a drinking behavior that mimics dipsogenic tachyphylaxis.
Water deprivation-induced sodium appetite
2010, Physiology and BehaviorCitation Excerpt :A transitory enhancement has been also described in some experiments in which repeated dehydration was produced by the furosemide/extracellular dehydration protocol [82]. Such decrease in the strength of the enhancement in the need-induced sodium intake resembles the tachyphylaxis of thirst induced by repeated injections of angiotensin II [83]. However, the tachyphylaxis is induced by injections at narrow intervals.