Genetic selection disrupts stability of mouse brain weight development

Abstract

Fuller Brain Weight Selection lines are well differentiated for 42-day brain weight and a high degree of homogeneity for trait-relevant genes is indicated. Using these lines, random bred descendants of the foundation population and an inbred line, biometrical analysis of brain growth from birth to 23 days was attempted. Whilde strain means differ as expected, within and between litter variances for genetically heterogenous mice were typically no greater than for more genetically homogenous selected lines. Possible explanations involving gestational age, intra-uterine and postnatal competition and ontogenetic buffering are discussed.