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2022, Food and Chemical ToxicologyInduction of Dickkopf-1 contributes to the neurotoxicity of MPP<sup>+</sup> in PC12 cells via inhibition of the canonical Wnt signaling pathway
2013, NeuropharmacologyCitation Excerpt :PD is a progressive neurodegenerative disease with selective loss of dopaminergic neurons in the substantia nigra, but the pathogenesis of PD still needs to be elucidated. PC12 cells, possessing dopamine synthetic, metabolistic and transporting enzymes (Hatanaka, 1981; Rebois et al., 1980; Tuler et al., 1989), have been widely used to study MPP+-induced neurotoxicity and PD. Exposed PC12 cells to MPP+ (1000 μM) for different time periods, we detected a significant loss of PC12 cells only after 48 h.
Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells
2011, Nitric Oxide - Biology and ChemistryTempol attenuates cocaine-induced death of PC12 cells through decreased oxidative damage
2011, European Journal of PharmacologyCitation Excerpt :In the present study we utilized the well established PC12 cell line system. PC12 cells, a clonal rat pheochromocytoma cell line (Hatanaka, 1981; Kadota et al., 1995; Rebois et al., 1980; Tuler et al., 1989), have frequently been used as a model for dopaminergic neurons and many studies have shown that these cells synthesize dopamine (Pothos et al., 1996; Presse et al., 1997) and express dopamine receptors (Kadota et al., 1996; Zachor et al., 2000). Cocaine has already been demonstrated to interfere with uptake and extracellular dopamine levels in PC12 cells.
Analysis of the role of nerve growth factor in promoting cell survival during endoplasmic reticulum stress in PC12 cells
2011, Methods in EnzymologyCitation Excerpt :The use of siRNAs is a very powerful way to analyze specific molecular mechanisms, and we utilize siRNAs against PUMA and Bim in our method. Pheochromocytoma 12 (PC12) cells were first established by L.A. Greene in 1976 (Greene and Tischler, 1976) and many subclones with slight phenotypic variations have since been established (Hatanaka, 1981; Ikenaka et al., 1990; Sano et al., 1988). We used the PC12h cell line in our current method, which is one of the established PC12 subclones and is resistant to serum-free (SF) conditions for at least 24 h.