Elsevier

Brain Research

Volume 201, Issue 2, 17 November 1980, Pages 471-474
Brain Research

Altered pain perception in hypertensive humans

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Abstract

Sensory and pain thresholds to electrical stimulation of tooth pulps were measured in normotensive and essential hypertensive unmedicated human subjects. In both adult and young subjects there was a significant correlation between blood pressure and pain sensitivity: hypertensives had a higher threshold for sensation of pain in the tooth-pulp test than normotensive controls. An interrelationship between blood pressure and pain regulation is suggested.

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    Patients were excluded if they had a systemic disease including other types of diabetes, uncontrolled diabetes, prediabetes, or any diseases that could affect the results (eg, hypertension [patients were considered to be hypertensive if their blood pressure was ≥140 mm Hg systolic or 90 mm Hg diastolic]7, hyperparathyroidism, hyperthyroidism, chronic renal disease, or hepatic disease). In addition, patients were excluded if they had diseases that could cause injury to the head and neck nervous system (stroke, multiple sclerosis, and so on)3,4,6,7,11,21 as well as other conditions that might affect the results such as cancer; pregnancy; or taking corticosteroids, ibuprofen, opium, or other medications such as gabapentin or phenytoin22. Further reasons for exclusion were trauma history, severe periodontal disease, orthodontic brackets or recent history of orthodontic treatment, extensive caries or restorations, apical periodontitis, teeth that had root canal treatment, and teeth with crowns5,14,23,24.

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Hadassah Dentistry School, Jerusalem, Israel.

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