Efferent connections of the septal area in the rat: An analysis utilizing retrograde and anterograde transport methods

doi:10.1016/0006-8993(77)90088-9

Brain Research

Volume 119, Issue 1, 1 January 1977, Pages 1-20

https://doi.org/10.1016/0006-8993(77)90088-9 Get rights and content

Summary

Experiments were performed by either retrograde (horseradish peroxidase histochemistry) or anterograde ([³H]leucine radioautography) transport methods to determine the efferent connections of the septum in the rat. It was observed that the dorsal septum projects to the lateral preoptic area, lateral hypothalamus, periventricular hypothalamus and midline thalamus. Fibers from the ventral half of the septum project topographically to the hippocampal formation, thalamus, hypothalamus and midbrain. Specifically, neurons located along the midline in the vertical limb of the diagonal band project through the dorsal fornix to all CA fields of the dorsal hippocampus and adjacent subicular cortex. Other fibers from this region project through the stria medullaris to the medial habenular nucleus and anteromedial nucleus of the thalamus, and through the medial forebrain bundle to the pars posterior of the medial mammillary nucleus. Cells located immediately lateral to the midline in the vertical limb of the diagonal band project through the medial part of the fimbria to all CA fields of the posterior hippocampus and adjacent subicular cortex. Other fibers which originate from this region project through the stria medullaris to both the medial and lateral habenular nuclei and the paratenial nucleus of the thalamus, and through the medial forebrain bundle to the pars posterior of the medial mammillary nucleus. Cells located in the intermediolateral septum project through the lateral part of the fimbria to all CA fields of the ventral hippocampus and adjacent subicular and entorhinal cortices. These cells also send fubers through the stria medullaris to the lateral habenular nucleus and mediodorsal thalamic nucleus. Other axons arising from these cells descend through the medial forebrain bundle to terminate in a region dorsal to the interpeduncular nucleus. Fibers from the most lateral part of the ventral septum (i.e., bed nucleus of the anterior commissure) project through the stria terminalis to the ventral subiculum. In addition, cells located in the horizontal limb of the diagonal band project massively to the pars posterior of the medial mammillary nucleus and the ventral tegmental area, and amygdala.

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Efferent connections of the septal area in the rat: An analysis utilizing retrograde and anterograde transport methods

Summary

Exp. Neurol.

Exp. Neurol.

Exp. Neurol.

Brain Research

Exp. Neurol.

Exp. Neurol.

Brain Research

Electroenceph. clin. Neurophysiol.

Exp. Neurol.

Brain Research

Brain Research

Exp. Neurol.

Brain Research

An experimental study of the hippocampal connections of the cingulate cortex in the rabbit

Brain

Terminal degeneration in the diencephalon after ablation of frontal cortex in the cat

J. Anat. (Lond.)

Experimental studies on the fiber connections of the rhinencephalon. I. Albino rat

Med. J. Osaka Univ.

On the connexions of the medial cell group of thalamus

Brain

Projections from the nuclei of the diagonal bands: an autoradiographic study in the albino rat

Neurosci. Abstr.

Memory loss due to hippocampal lesions

Arch. Neurol. (Chic.)

Thalamic projections in the cingulum bundle to the parahippocampal cortex of the rat

Anat. Rec.

Surgical aspects of the hypothalamus

The section of the fornix in the surgical treatment of certain epilepsies

Trans. Amer. neurol. Assoc.

Bilateral destruction of hippocampus (cornu ammonis) in case of dementia

Mschr. Psychiat. Neurol.

The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique

J. Histochem. Cytochem.

Degeneration in the post-commissural fornix and in the mammillary peduncle of the rat

J. Anat. (Lond.)

Afferent fibers to the dorso-medial thalamic nucleus in the cat

J. Anat. (Lond.)

The diencephalon of the albino rat

J. comp. Neurol.