The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro
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Chokeberry (Aronia melanocarpa) juice modulates 7,12-dimethylbenz[a]anthracene induced hepatic but not mammary gland phase I and II enzymes in female rats
2011, Environmental Toxicology and PharmacologyCitation Excerpt :DMBA is a procarcinogen that requires metabolic conversion to its ultimate carcinogenic metabolite, DMBA-3,4-dihydrodiol-1,2-epoxide by either CYP1A1 or CYP1B1 (Kleiner et al., 2004). Besides these P450 isozymes, also CYP2B1 and 2C6 are involved in metabolic activation of DMBA (Lambard et al., 1991). Our current study showed similarity to our previous observations in male Wistar rats.
Mechanisms of mammary cancer chemoprevention by organoselenium compounds
2004, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisComparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
2003, Chemico-Biological InteractionsCitation Excerpt :Like other carcinogens, DMBA has to be metabolized into an electrophilic species that can react irreversibly with nucleophilic sites on DNA, thereby leading to mutation, if the damage is not repaired and, subsequently, to carcinogenesis [35]. Multiple P450 isozymes in rat liver are known to activate DMBA to the corresponding proximate and ultimate carcinogenic forms; the cytochrome P450 2C subfamily appears to play a significant role [36–38]. Although there is evidence that the ultimate carcinogenic diol epoxide metabolites are stable, and can be transported to extrahepatic tissue where binding to DNA can occur [39–41], the metabolic capacity of the target organ (mammary gland) should not be dismissed.
The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines: Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine
2002, Biochemical PharmacologyCitation Excerpt :Recently published study on a benzo[a]pyrene (BP) induced lung tumor in mice confirmed that CAF is among cancer preventive agents [23]. Both DMBA and BP are procarcinogens and require biological activation by cytochromes P450 [24,25]. These enzymes also metabolize CAF and it was proposed that protective effect of CAF is a result of competitive interaction with cytochromes [26,27].