Research paperLipid peroxidation as a possible cause of ochratoxin a toxicity
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2018, Food and Chemical ToxicologyCitation Excerpt :OTA-enhanced lipid peroxidation affects the permeability of the plasma membrane to Ca2+ and thus impairs calcium homeostasis by enhancing Ca2+ influx, releasing it from intracellular stores and influencing calcium-sensitive channels. In the presence of NADPH-CYP450 reductase, OTA–Fe3+ complex facilitates the reduction of Fe3+, and the OTA–Fe2+ complex formed initiates the appearance of free radicals, leading to lipid peroxidation (Omar et al., 1990; Rahimtula et al., 1988). A significant increase in the levels of protein nitrotyrosine residues was observed with OTA, and it was also found that Nrf2 activators could prevent OTA-induced protein nitration.
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