Proline hydroxylation by cell free extract of a streptomycete
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Cited by (28)
Engineering endogenous L-proline biosynthetic pathway to boost trans-4-hydroxy-L-proline production in Escherichia coli
2021, Journal of BiotechnologyCitation Excerpt :As a valuable chiral amino acid, t4HYP has aroused extensive interests due to its versatile roles in medicine, biochemistry, food, cosmetic and other aspects of industry (Remuzon, 1996). For instance, t4HYP is a natural constituent of pharmaceutical intermediates of echinocandins, etamycin, and actinomycins (Wichmann et al., 1989; Onishi et al., 1984). t4HYP is a fundamental and versatile chiral building block in the chemical syntheses of a large variety of chiral pharmaceutical molecules such as carbapenems, lycoperdic acid, benzodiazepines, and naphthyridones (Brands et al., 2002; Remuzon, 1996; Krapcho et al., 1988).
Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles
2020, Bioorganic ChemistryCitation Excerpt :Hydroxyprolines and modified (e.g. by methylation) prolines are present in many peptide-based natural products [10–12]. In some cases, the proline-hydroxylations occur prior to peptide-synthetase-catalysed oligomerisation [10–12]. Following from pioneering labelling [10,11] and purification studies [13], recombinant forms of proline-hydroxylases (PHs) have been produced (Fig. 1) [1,14–27].
Efficient production of trans-3-hydroxyproline by a bacterial trans-3-proline hydroxylase and characterization of enzymatic properties
2019, Biochemical Engineering JournalCitation Excerpt :L-hydroxyprolines (L-Hyps) are valuable building blocks for the synthesis of important pharmaceuticals such as carbapenem antibiotics and antispastic agents [1–4].
Efficient production of trans-4-hydroxy-L-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli
2018, Journal of Bioscience and BioengineeringMicrobial screening in hydroxylation of l-proline
2006, Tetrahedron Letters