Regular paperModification of fluidity and lipid—protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency
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2016, Cell MetabolismCitation Excerpt :Our results provide in vivo support for the hypothesis that passive transport of FAs across a permissive enterocyte membrane predominates in the context of bolus lipid challenge in vivo. Interestingly, the phospholipid profile of Lpcat3 KO enterocytes (decreased 18:2-containing PC, decreased 20:4-containing PC, and increased in 18:1- and 20:3-containing PC) is similar to that previously observed in EFA-deficient mucosa (Christon et al., 1989; Enser and Bartley, 1962; Yurkowski and Walker, 1971). EFA deficiency has been recognized to be associated with fat malabsorption for decades (Clark et al., 1973; Hjelte et al., 1990; Levy et al., 1992; Barnes et al., 1941), but the underlying mechanisms have never been defined.
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